49ers Lose Evans, Trent Williams and Lenoir to Injuries Against Cardinals

Already without Nick Bosa, San Francisco saw Mike Evans, Trent Williams and Deommodore Lenoir leave its Week 3 game against Arizona with injuries.

The San Francisco 49ers hosted the Arizona Cardinals at Levi's Stadium in Week 3 of the NFL season, and they did so without Nick Bosa, who was unavailable for the game. Once the game kicked off, the injury news only multiplied for the home team. During the contest, Mike Evans, Trent Williams and Deommodore Lenoir all exited with injuries.

Defensive back Deommodore Lenoir was forced out of the game after an accidental helmet-to-helmet hit from teammate Fred Warner, an exit first reported by Matt Barrows of The Athletic. The 49ers confirmed soon after on their official X account that Lenoir was undergoing evaluation for a concussion. There was no word in the report on a potential return.

Trent Williams, the 49ers' offensive tackle, went down later in the game, hurt on the play that produced Christian McCaffrey's short touchdown run. He was slow to rise after leading with his helmet into a linebacker, and the injury appeared to be to his head. It was the second head-related concern of the game for San Francisco.

Evans, for his part, left the field on a cart and was taken to the locker room. The report described his injury as concerning but offered no specifics on what happened or how severe it might be. No diagnosis or timetable accompanied the account. He had also played a central role in the game's biggest offensive play.

That moment came in the first quarter, when Evans pitched the ball back to Deebo Samuel on a hook-and-ladder that ended as an 80-yard touchdown. Samuel took it the rest of the way. San Francisco kept control from there, holding a 10-6 edge on the scoreboard in the second quarter to extend its advantage.

Arizona pulled closer as the game went on, cutting the deficit to three points not long after the fourth quarter began. Quarterback Jacoby Brissett then found Jeremiyah Love for a one-yard touchdown pass, making the score 23-20. San Francisco still led in total yardage early in the fourth quarter.

Through the air, Brock Purdy had piled up more than 250 passing yards and a pair of touchdown throws by the late stages of the fourth quarter. The report noted that his passing had not been as efficient as his usual standard, even with the numbers he posted.

Health problems have been a recurring issue for coach Kyle Shanahan's team in recent seasons, and the Week 3 toll fit that pattern. The report described the San Francisco roster as one of the deepest in the NFL, a cushion for a group carrying Super Bowl hopes.

The account was published with the game still in progress and Arizona trailing 23-20 in the fourth quarter. No final score was included, and no further updates were available on Evans, Williams or Lenoir.